FOXA1 is one of three members of the FOXA family, a subset of the forkhead family of transcription factors which play vital roles in development.
It has also been implicated in the development of a number of other organs including the androgen and estrogen regulated tissues of the breast and prostate.
FOXA1 modulates the transcriptional activity of nuclear hormone receptors and regulates apoptosis by inhibiting the expression of BCL-2.
It is an essential protein for the transcriptional activity of both androgen receptor (AR) and estrogen receptor-alpha (ER).
FOXA1 plays a pivotal role from early stage cancer through to drug resistant and metastatic disease.
FOXA1 is not only an attractive therapeutic target but could potentially function as a novel biomarker.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:293 Cell Lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human FOXA1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Peptide corresponding to 17aa from human FOXA1.
