84-4369-06　APBA1, NT (X11A, LIN10, MINT1, X11Alpha, X11, Amyloid beta A4 Precursor Protein Binding Family A Member 1, Adapter Protein X11alpha, Mint-1) 100ug　352114

特徴

• The Amyloid beta 4 (A4) precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family and a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP).
• APBA1 stabilizes APP and inhibits production of proteolytic APP fragments including the Ab peptide that is deposited in the brains of Alzheimer's disease patients.
• It is thought to be involved in signal transduction processes and is a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
• APBA1 can also bind to CASK, a multidomain scaffolding protein involved in brain development and synapse formation.
• Applications:Suitable for use in Immunofluorescence, ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 20ug/mlWestern Blot: 0.5ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Rat Brain Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.