84-4368-62　RBBP4, CT (RbAp48, Histone-binding protein RBBP4, Retinoblastoma binding protein 4, NURF55) 100ug　350815

特徴

• Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.
• This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins.
• It is present in protein complexes involved in histone acetylation and chromatin assembly.
• And it is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation.
• This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing.
• It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation.
• This protein also seems to be involved in transcriptional repression of E2F-responsive genes.
• Three transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml Immunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.