84-4368-41　PGK1, CT (Phosphoglycerate Kinase 1, PGKA, Cell Migration-inducing Gene 10 Protein, Primer Recognition Protein 2, 3-Phosphoglycerokinase) 100ug　350782

特徴

• PGK1 (Phosphoglycerate Kinase 1), also known as PGKA, is an enzyme that in humans is encoded by the PGK1 gene.
• The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate.
• The encoded protein may also act as a cofactor for polymerase alpha.
• Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin.
• The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions.
• Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment.
• Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.