84-4368-25　DDB2 (Damage-specific DNA Binding Protein 2, DNA Damage-binding Protein 2, DDB p48 Subunit, DDBb, UV-damaged DNA-binding Protein 2, UV-DDB 2, UV-DDB2) 100ug　350593

特徴

• DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.
• This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA.
• This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage.
• And this subunit appears to be required for DNA binding.
• Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
• Two transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.