84-4368-08　PTP4A2, NT (Protein tyrosine phosphatase type IVA 2, member 2) 100ug　350800

特徴

• Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.
• The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family.
• PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes.
• PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif.
• This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation.
• This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.
• Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis.
• Alternatively spliced transcript variants have been described.
• Related pseudogenes exist on chromosomes 11, 12 and 17.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.