84-4367-33　MAOA, CT (Amine oxidase [flavin-containing] A, Monoamine oxidase A) 100ug　350729

特徴

• MAOA(Monoamine oxidase A), also known as Amine Oxidase (Flavin-containing) A, is an enzyme that in humans is encoded by the MAO-A gene.
• MAOA is an isozyme of monoamine oxidase which is also mapped on Xp11.3.
• MAOA degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin.
• The protein localizes to the outer mitochondrial membrane.
• Mutation in MAOA results in monoamine oxidase deficiency, or Brunner syndrome.
• In humans, there is a 30-base repeat sequence repeated in one of several different numbers of times in the promoter region of the gene coding for MAOA.
• MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder.
• Inhibition of MAOA prevented apoptosis, and serum starvation of cortical brain cells from Maoa-deficient mice resulted in reduced apoptosis compared with wildtype mice.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml Immunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.