84-4367-22　KCNA5, CT (Kv1.5, HPCN1, Voltage-gated potassium channel HK2, Potassium voltage-gated channel subfamily A member 5) 100ug　350701

特徴

• Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene.
• Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints.
• KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily.
• This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment.
• It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion.
• This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.
• Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death.
• KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.