84-4366-98　HDAC6, NT (Histone deacetylase 6, KIAA0901, JM21) 100ug　350651

特徴

• HDAC6, also called KIAA0901, is a member belongs to class II of the histone deacetylase/ acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC6 gene.
• The HDAC6 gene is mapped to chromosome Xp11.23.
• HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other.
• The protein possesses histone deacetylase activity and represses transcription.
• HDAC6 functions as a tubulin deacetylase.
• And it is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex.
• HDAC6 could bind both polyubiquitinated misfolded proteins and dynein motors, thereby recruiting misfolded protein cargo to dynein motors for transport to aggresomes.
• Furthermore, expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy- dependent manner.
• HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.