Clusterin (apolipoprotein J) is a 75-80kD disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis.
In humans, clusterin is encoded by the CLU gene.
This protein has several synonyms: dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI).
Clusterin was mapped to mouse chromosome 14.
Clusterin is a ubiquitously expressed molecule thought to influence a variety of processes including cell death.
In the brain, it accumulates in dying neurons following seizures and hypoxic-ischemic (H-I) injury.
clusterin may be a new therapeutic target to modulate non-caspase-dependent neuronal death following acute brain injury.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
Specificity：Recognizes human CLU.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human CLU expressed in E. coli. Species sequence homology: mouse (76.1%) and rat (75.2%)
