84-4366-44　RANTES (CCL5, C-C motif chemokine 5, SCYA5, Chemokine (C-C motif) ligand 5, Regulated On Activation In Normal T-Cell Expressed And Secreted) 100ug　350813

特徴

• Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene.
• It is also known as RANTES.
• This gene is one of several chemokine genes clustered on the q-arm of chromosome 17.
• Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
• The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide.
• This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils.
• It causes the release of histamine from basophils and activates eosinophils.
• This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells.
• It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
• Alternative splicing results in multiple transcript variants that encode different isoforms.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.