Chemokine(C-C motif) ligand 4, also known as CCL4, is a protein which in human is encoded by the CCL4 gene.
By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23.
It is a CC chemokine with specificity for CCR5 receptors.
And it is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.
CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.
Performing-low memory CD8+ T cells that normally synthesize CCL4.
Based on functional analysis of CCL4, one or more additional beta chemokine receptors that transduce CCL4 signals must also exist.
MIP-1alpha and CCL4 have been shown to lack affinity for the erythrocyte surface chemokine receptor/ Duffy antigen that binds many alpha as well as beta chemokines.
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
Specificity：Recognizes human CCL4.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human CCL4 expressed in E. coli. Species sequence homology: mouse (76.8%) and rat (79.7%).
