84-4365-97　KLF6 (Krueppel-like factor 6, B Cell-derived Protein 1, BCD1, CBA1, Core Promoter Element Binding Protein, COPEB, CPBP, GBF, GC-rich Sites-binding Factor GBF, PAC1, Proto-oncogene BCD1, Suppressor of Tumorigenicity 12 Protein, ST12, Transcription Factor Zf9, ZF9) 100ug　350707

特徴

• Krueppel-like factor 6 (KLF6) is a protein that in humans is encoded by the KLF6 gene.
• It is a tumor suppressor gene which is located on 10p15.1.
• This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region.
• The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements.
• The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation.
• It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters.
• The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.