Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching.
Regulates neurite fasciculation, branching and extension in the developing nervous system.
Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS.
Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity).
Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2.
This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration.
Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human RTN4.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa28-58 from human RTN4 at N-terminal, KLH conjugated. Species sequence homology: mouse, rat
