84-4364-16　KHDRBS1, ID (KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68kD protein, Sam68, p21 Ras GTPase-activating protein-associated p62, p68) 200ul　350450

特徴

• Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors.
• Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins.
• Role in G2-M progression in the cell cycle.
• Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP.
• Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.
• Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation.
• According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824).
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry, Other applications not tested.
• Recommended Dilution:Western Blot: 1:2000Immunohistochemistry (paraffin): 1:25Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.