Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen.
Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin.
Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.
Integrin alpha-5/beta-1 is a receptor for fibrinogen.
Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin.
Integrin alpha-4/beta-1 is a receptor for VCAM1.
It recognizes the sequence Q-I-D-S in VCAM1.
Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.
It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.
Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
Integrin alpha-V/beta-1 is a receptor for vitronectin.
Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro).
In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
Involved in promoting endothelial cell motility and angiogenesis.
May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.
Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation.
Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to the sequence around phosphorylation site of threonine 789(V-E-T(p)-V-V) derived from human Integrin beta1 .
