84-4358-55　BAD(phosphorylated Ser136) 100ul　307573

特徴

• The protein encoded by BAD gene is a member of the BCL-2 family.
• BCL-2 family members are known to be regulators of programmed cell death.
• This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity.
• Proapoptotic activity of this protein is regulated through its phosphorylation.
• Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein.
• Alternative splicing of this gene results in two transcript variants which encode the same isoform.
• Wang XQ, et al.
• (2001).
• J Biol Chem.276 (48): 44504-44511.
• Lee YI, et al.
• (2001).
• J Biol Chem.276 (20): 16969-16977.
• Maiti D, et al.
• (2001).
• J Biol Chem.276 (1): 329-333.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.