Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
May play a role in the control of granulocytic lineage proliferation or differentiation.
Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.Martin Oppermann, J.
Biol.
Chem., Mar 1999; 274: 8875.
Beatrix Pollok-Kopp, J.
Biol.
Chem., Jan 2003; 278: 2190 - 2198.
Ramtin Rahbar, J.
Virol., Jul 2006; 80: 7245 - 7259.
H Olbrich, J.
Leukoc.
Biol., Mar 1999; 65: 281.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Peptide corresponding to the sequence around phosphorylation site of Serine 349 (E-I-S(p)-V-G) derived from Human CCR5.
