84-4356-80　Progesterone Receptor (phosphorylated Ser294) 100ul　330636

特徴

• Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors.
• They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.
• The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes.
• They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT.
• Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen.
• Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy.
• In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy.
• The human gene encoding the progesterone receptor has been localized to 11q22.Chung HH, Sze SK, Tay AS, Lin VC (2014) J Biol Chem 289, 2180-94 Hagan CR, Knutson TP, Lange CA (2013) Nucleic Acids Res 41, 8926-42 Wang S, et al.
• (2013) J Biol Chem 288, 26265-74
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.