84-4356-57　FANCD2 (phosphorylated Ser222) 100ul　315665

特徴

• Required for maintenance of chromosomal stability.
• Promotes accurate and efficient pairing of homologs during meiosis.
• Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing.
• May participate in S phase and G2 phase checkpoint activation upon DNA damage.
• Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress.
• Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress.
• Promotes BRCA2/FANCD1 loading onto damaged chromatin.
• May also be involved in B-cell immunoglobulin isotype switching.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.