84-4355-51　Survivin (Phospho-Thr117) 100ul　336167

特徴

• Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis.
• Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis.
• Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules.
• The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
• May counteract a default induction of apoptosis in G2/M phase.
• The acetylated form represses STAT3 transactivation of target gene promoters.
• May play a role in neoplasia.
• Inhibitor of CASP3 and CASP7.
• Isoform 2 and isoform 3 do not appear to play vital roles in mitosis.
• Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.