84-4355-06　SP1(Phospho-Thr739) 100ul　335245

特徴

• Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli.
• Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses.
• Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).
• Binds also the PDGFR-a G-box promoter.
• May have a role in modulating the cellular response to DNA damage.
• Implicated in chromatin remodeling.
• Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter.
• Plays an essential role in the regulation of FE65 gene expression.
• Thiesen HJ,et al.(1990)Nucleic Acids Res.18(11):3203-9.
• Zutter MM,et al.(1997) Blood.90(2):678-89.
• Lou Z,et al.(2005)Cancer Res.65(3):1007-17
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.