May be involved in the regulation of dopamine release and transport.
Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies).
Induces fibrillization of microtubule-associated protein tau.
Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Takahashi T, et al.
J Biol Chem 2003 Oct 24; 278(43): 42225-33 Ahn BH, et al.
J Biol Chem 2002 Apr 05; 277(14): 12334-42 Negro A, et al.
FASEB J 2002 Feb; 16(2): 210-2 Goldberg, et al.
Nat.
Cell Biol.
2000; 2, 115-119.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to the sequence around phosphorylation site of serine 129 (M-P-S(p)-E-E) derived from Human a-Synuclein.
