Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models.
Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity.
Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1.
Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1.
Seems also to be a transcriptional repressor by itself.
May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.Hongzhe Li, J.
Biol.
Chem., Feb 2007; 282: 4943 - 4950.
Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
Thierry Virolle, J.
Biol.
Chem., Mar 2003; 278: 11802 - 11810.
Derek J.
Richard, Genes & Dev., Feb 2001; 15: 328.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human prostate apoptosis response protein-4.
