84-4352-18　Catenin, delta 1 (Cadherin-associated Src substrate, CAS, Catenin delta-1, CTNND, KIAA0384, p120, p120(cas), p120(ctn), p120cas, P120CAS, p120 Catenin, p120ctn, P120CTN) 100ul　309354

特徴

• Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity.
• Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability.
• Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
• Promotes GLIS2 C-terminal cleavage.Keirsebilck A., Genomics 50:129-146(1998).
• Nagase T., DNA Res.
• 4:141-150(1997).
• W.S., Sherwood J.K., Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.