84-4351-62　PAK1 (p21 Activated Kinase 1, p21-activated Kinase 1, PAK-1, Alpha PAK, Alpha-PAK, p21/Cdc42/Rac1-activated Kinase 1, p65-PAK, Serine/threonine-protein Kinase PAK1, Serine/threonine Protein Kinase PAK1) 100ul　327380

特徴

• The activated kinase acts on a variety of targets.
• Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway.
• Activated by CDC42 and RAC1.
• Involved in dissolution of stress fibers and reorganization of focal complexes.
• Involved in regulation of microtubule biogenesis through phosphorylation of TBCB.
• Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
• Alexander K, et al.
• (2004) Mol Cell Biol; 24: 2808-2819 Thiel DA, et al.
• (2002) Curr Biol; 12:1227-1232 Rashid T, et al.
• (2001) J.
• Biol.
• Chem; 276: 49043 - 49052.
• Applications:Suitable for use in Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:100-1:200Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.