Elk-1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily.
Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene.
The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade.
Alternatively spliced transcript variants encoding the same protein have been found for this gene Janknecht R, et al.
(1993) EMBO J.
12(13): 5097-5104.
Marais R, et al.
(1993) Cell 73:381-393.
Kortenjann M, et al.
(1994) Mol Cell Biol.
14:4815-4824.
Hill C S, et al.
(1995) Cell.
80:199-211.
Cavigelli M, et al.
(1995) EMBO J.
14:5957-5964.
Applications:Suitable for use in Immunofluorescence and Western Blot.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:100-1:200Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to the sequence around aa387-391 (P-R-S-P-A) derived from Human Elk1.
