Deubiquitinating enzyme that regulates the degradation of various proteins.
Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation.
Involved in decreased protein synthesis in atrophying skeletal muscle.
Modulates transcription of major myofibrillar proteins.
Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.
Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination.
Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner.
Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis.
Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.
Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.Nagase T., DNA Res.
5:355-364(1998).
The MGC Project Team, Genome Res.
14:2121-2127(2004).
Beausoleil S.A., Proc.
Natl.
Acad.
Sci.
U.S.A.
101:12130-12135(2004).
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human Mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to internal of human USP19.
