84-4350-75　RMP 100ul　332919

特徴

• Involved in gene transcription regulation.
• Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription.
• May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells.
• Required for cell survival in ovarian cancer cells.
• Together with UXT, associates with chromatin to the NKX3-1 promoter region.
• Antagonizes transcriptional modulation via hepatitis B virus X protein.
• Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling.
• The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors.
• Mediates inhibition of PPP1CC phosphatase activity in mitochondria.
• Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner.
• Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.