84-4348-30　DLX5 100ul　313609

特徴

• Transcriptional factor involved in bone development.
• Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation.
• Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation.
• Stimulates SP7 promoter activity during osteoblast differentiation.
• Promotes cell proliferation by up-regulating MYC promoter activity.
• Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton.
• Binds to the homeodomain-response element of the ALPL and SP7 promoter.
• Binds to the MYC promoter.
• Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.Ota T., Nat.
• Genet.
• 36:40-45(2004).
• Hillier L.W., Nature 424:157-164(2003).
• Willis D.M., J.
• Biol.
• Chem.
• 277:37280-37291(2002).
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.