84-4347-51　60S Ribosomal Protein L10 100ul　303947

特徴

• Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
• Together these subunits are composed of four RNA species and ~80 structurally distinct proteins.
• This gene encodes a ribosomal protein that is a component of the 60S subunit.
• The protein belongs to the L10E family of ribosomal proteins.
• It is located in the cytoplasm.
• In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo.
• This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor.
• This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor.
• Alternative splicing results in multiple transcript variants.
• This gene also uses multiple polyA signals, with the 3'-most polyA signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand.
• This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron.
• As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.Dowdy S.F., Nucleic Acids Res.
• 19:5763-5769(1991).
• van den Ouweland A.M.W., Hum.
• Mol.
• Genet.
• 1:269-273(1992).
• Kaneko K., Hum.
• Mol.
• Genet.
• 1:529-533(1992).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.