84-4347-37 FAS 100ul 315704
特徴
- Receptor for TNFSF6/FASLG.
- The adapter molecule FADD recruits caspase-8 to the activated receptor.
- The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
- FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
- The secreted isoforms 2 to 6 block apoptosis (in vitro).Michael J.
- Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000; 278: 354.
- Morgan Jenkins, J.
- Immunol., Aug 1999; 163: 1195.
- Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999; 91: 1678 - 1684.
- JOS E.
- CARDIER, FASEB J, Nov 1999; 13: 1950.
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- Applications:Suitable for use in Western Blot and Immunohistochemistry.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
- Specificity：Human
- Isotype：IgG
- Calc Applications Abbrev：IHC WB
- Calc Crossreactivity：Hu
- Immunogen：Synthetic peptide corresponding to C-terminal of human Fas.
- Shelf Life：1year
- Swiss Prot Number：P25445
- EU Commodity Code：30021010
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- 製品の仕様は予告なく変更になる場合がございます。最新仕様はメーカーホームページをご確認ください。
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