Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein).
Requires the other members of the gamma-secretase complex to have a protease activity.
May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.
Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex.
Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling.
May also play a role in hematopoiesis.Yanzhu Liu, J.
