The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems.
An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing.
These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI.
Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).Xiao-Feng Le, Cancer Res., Jul 2000; 60: 3522 - 3531.
Samuel D.
H.
Chan, J.
Biol.
Chem., Sep 1995; 270: 22608.
Daniel C.
Gamett, J.
Biol.
Chem., Aug 1995; 270: 19022.
Mohammed Rahmatullah, Mol.
Cell.
Biol., Nov 1998; 18: 6245 - 6252.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human NRG1 isoform-10.
