Glucagon plays a key role in glucose metabolism and homeostasis.
Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia.
Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
GLP-1 is a potent stimulator of glucose-dependent insulin release.
Play important roles on gastric motility and the suppression of plasma glucagon levels.
May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin.
Have growth-promoting activities on intestinal epithelium.
May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion.
Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation.
Inhibits beta cell apoptosis.
GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.
The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action.
Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal.
Stimulates intestinal glucose transport and decreases mucosal permeability.
Oxyntomodulin significantly reduces food intake.
Inhibits gastric emptying in humans.
Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity.
May play an important role in intestinal mucosal growth in the early period of life.Edoardo C.
Aromataris, J.
Physiol., Jun 2006; 573: 611 - 625.
Xiao C.
Li, Hypertension, Mar 2006; 47: 580 - 585.
Kirstan A.
Vessey, Invest.
Ophthalmol.
Vis.
Sci., Nov 2005; 46: 3922 - 3931.
Xiaosong Ma, Mol.
Endocrinol., Jan 2005; 19: 198 - 212.
Applications:Suitable for use in Immunofluorescence and Western Blot.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:100-1:500Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human glucagon.
