Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes.
Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development.
Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission.
Crucial for normal neuronal development, distribution, and electrical activity in the neocortex.
Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis.
Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.
May also be involved in neurogenesis and in the development of cortical architecture By similarity.
Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.Leifer D., Proc.
Natl.
Acad.
Sci.
U.S.A.
90:1546-1550(1993).
McDermott J.C., Mol.
Cell.
Biol.
13:2564-2577(1993).
Wang A.H., Mol.
Cell.
Biol.
19:7816-7827(1999).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human Mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthesized non-phosphopeptide derived from human MEF2C around the phosphorylation site of serine 396 (P-V-S(p)-P-P).
