Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs).
Adhesion with HA plays an important role in cell migration, tumor growth and progression.
Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.
Altered expression or dysfunction causes numerous pathogenic phenotypes.
Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Teriete P.,et.al(2004) Mol.
Cell 13:483-496 Bartolazzi A.
(2003)Melanoma Res.
13:325-337 Liu T.et.al (2005)J.
Proteome Res.
4:2070-2080
Applications:Suitable for use in Immunofluorescence and Western Blot.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:100-1:200Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human Rat
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu Rt
Immunogen：Peptide corresponding to the sequence around aa734-738(Q-N-V-D-M) derived from human CD44.
