Plays a general role in caspase independent cell death of tumor cells.
The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production.
The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Christofk, H.R.
et al.
(2008) Nature 452, 230-3.
Mazurek, S.
et al.
(2005) Semin Cancer Biol 15, 300-8.
Dombrauckas, J.D.
et al.
(2005) Biochemistry 44, 9417-29.
Hitosugi, T.
et al.
(2009) Sci Signal 2, ra73.
WB IF Recommended dilution: Predicted MW: 60kd, Western blotting: 1:1000
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human Mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Peptide corresponding to the sequence around aa399-403(V-R-A-S-S) derived from human PKM1.
