84-4341-64　RHOB (Ras Homolog Family Member B, ARH6, ARHB, RHOH6, MST081, MSTP081) 100ul　332647

特徴

• Mediates apoptosis in neoplastically transformed cells after DNA damage.
• Not essential for development but affects cell adhesion and growth factor signaling in transformed cells.
• Plays a negative role in tumorigenesis as deletion causes tumor formation.
• Involved in intracellular protein trafficking of a number of proteins.
• Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.
• Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
• Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.
• Required for genotoxic stress-induced cell death in breast cancer cells.Chardin P., Nucleic Acids Res.
• 16:2717-2717(1988).
• Puhl H.L.
• III, Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
• Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.