GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA.
Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix.
Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.Furukawa Y., Biochem.
Biophys.
Res.
Commun.
284:643-649(2001).
The MGC Project Team, Genome Res.
14:2121-2127(2004).
Kawasoe T., Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to internal of human RHG9.
