84-4341-50　RGS14 100ul　332559

特徴

• Acts as a regulator of G protein signaling (RGS).
• Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI).
• Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2.
• Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3.
• May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways.
• Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1.
• Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism.
• Plays a role in cell division.
• Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth.
• May be involved in visual memory processing capacity and hippocampal-based learning and memory.Lopez-Aranda M.F., Eur.
• J.
• Neurosci.
• 23:2971-2982(2006).
• Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
• Puhl H.L.
• III, Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.