Probably important in the regulation of neuronal excitability.
May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea.
KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect.
Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.Kubisch C., Cell 96:437-446(1999).
Gregory S.G., Nature 441:315-321(2006).
Selyanko A.A., J.
Physiol.
(Lond.) 522:349-355(2000).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-terminal of human KCNQ4.
