84-4340-20　MLF1 100ul　324099

特徴

• Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation.
• Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels.
• Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.
• Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.Yoneda-Kato N., Oncogene 12:265-275(1996) [PubMed: 8570204].
• Hanissian S.H., Oncogene 23:3700-3707(2004) [PubMed: 15116101].
• Yoneda-Kato N., EMBO J.
• 24:1739-1749(2005) [PubMed: 15861129].
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.