RNA-binding protein implicated in the regulation of several post-transcriptional events.
Involved in pre-mRNA alternative splicing, mRNA translation and stability.
Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.
Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition.
Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs.
Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB.
Promotes exclusion of exon 11 of the INSR pre-mRNA.
Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.
Increases translation and controls the choice of translation initiation codon of CEBPB mRNA.
Increases mRNA translation of CEBPB in aging liver By similarity.
Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3.
Mediates rapid cytoplasmic mRNA deadenylation.
Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation.
Required for completion of spermatogenesis By similarity.
Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs).
Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs.
Binds to the IR RNA.
Binds to the 5'-region of CDKN1A and CEBPB mRNAs.
Binds with the 5'-region of CEBPB mRNA in aging liver.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CUG-BP1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to internal of human CUG-BP1.
