Transcriptional regulator that controls a genetic switch in male development.
It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells By similarity.
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons By similarity.
Involved in different aspects of gene regulation including promoter activation or repression By similarity.
Promotes DNA bending.
SRY HMG box recognizes DNA by partial intercalation in the minor groove.
Also involved in pre-mRNA splicing.
Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.Sinclair A.H., Nature 346:240-244(1990).
Su H., Am.
J.
Hum.
Genet.
52:24-38(1993).
Behlke M.A., Genomics 17:736-739(1993).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to internal of human SRY.
