84-4333-44　EPHB2 100ul　314973

特徴

• Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
• The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
• Functions in axon guidance during development.
• Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex.
• Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk.
• Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses.
• Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation.
• Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production.
• Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca.
• May function as a tumor suppressor.Kiyokawa E., Cancer Res.
• 54:3645-3650(1994).
• Ikegaki N., Hum.
• Mol.
• Genet.
• 4:2033-2045(1995).
• Tang X.X., Oncogene 17:521-526(1998).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.