84-4332-52 OPG (TNFRSF11B, OCIF, OPG, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis Inhibitory factor, Osteoprotegerin) 100ul 337694
特徴
- Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
- Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro.
- Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B.
- May also play a role in preventing arterial calcification.
- May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis.
- TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.Simonet W.S., Cell 89:309-319(1997).
- Yasuda H., Endocrinology 139:1329-1337(1998).
- Morinaga T., Eur.
- J.
- Biochem.
- 254:685-691(1998).
- Applications:Suitable for use in Western Blot.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:3000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
- Specificity：Human Mouse
- Isotype：IgG
- Calc Applications Abbrev：WB
- Calc Crossreactivity：Hu Mo
- Immunogen：Synthetic peptide corresponding to Internal of human TR11B.
- Shelf Life：1year
- Swiss Prot Number：O00300
- EU Commodity Code：30021010
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