84-4330-65　Integrin b1(CD29) 100ul　320607

特徴

• Integrins a-1/beta-1, a-2/beta-1, a-10/beta-1 and a-11/beta-1 are receptors for collagen.
• Integrins a-1/beta-1 and a-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
• Integrins a-2/beta-1, a-3/beta-1, a-4/beta-1, a-5/beta-1, a-8/beta-1, a-10/beta-1, a-11/beta-1 and a-V/beta-1 are receptors for fibronectin.
• a-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.
• Integrin a-5/beta-1 is a receptor for fibrinogen.
• Integrin a-1/beta-1, a-2/beta-1, a-6/beta-1 and a-7/beta-1 are receptors for lamimin.
• Integrin a-4/beta-1 is a receptor for VCAM1.
• It recognizes the sequence Q-I-D-S in VCAM1.
• Integrin a-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.
• It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
• Integrin a-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.
• a-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
• Integrin a-V/beta-1 is a receptor for vitronectin.
• Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
• Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro).
• In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
• When associated with a-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
• Involved in promoting endothelial cell motility and angiogenesis.
• May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.
• Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation.
• Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.