MTSS1 (metastasis suppressor 1), also known as MIM, MIMA or MIMB, is a 755aa protein that contains one Actin-binding WH2 (Wiskott-Aldrich syndrome protein homology-2) domain and one IMD domain.
Expressed in a variety of tissues including testis, thymus, prostate, spleen, colon, uterus and blood, MTSS1 is thought to bind to Actin and, via this binding, may affect the dynamics of the cytoskeleton.
Through its association with the cytoskeleton, MTSS1 plays a role in controlling the progression and metastasis of carcinomas in various organ sites throughout the body and, when expressed at normal levels, functions as a tumor suppressor.
Overexpression of MTSS1 results in the formation of abnormal actin structures, an event that may lead to tumorigenesis.
Three isoforms of MTSS1 exist due to alternative splicing events.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:1000-1:2000Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 40% glycerol.
