84-4302-89　GPR124 50ul　317762

特徴

• Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis.
• These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1).
• TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues.
• TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once.
• TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis.
• TEM7 is highly expressed in tumor endothelium and neurons.
• Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:2000-1:5000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.